[R668.Ebook] Ebook The Billion Dollar Molecule: One Company's Quest for the Perfect Drug, by Barry Werth

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The Billion Dollar Molecule: One Company's Quest for the Perfect Drug, by Barry Werth

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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing -- atom by atom -- both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS.
You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

• Sales Rank: #132902 in Books
• Brand: Werth, Barry
• Published on: 1995-03-01
• Released on: 1995-03-01
• Original language: English
• Number of items: 1
• Dimensions: 8.44" h x 1.20" w x 5.50" l, .90 pounds
• Binding: Paperback
• 464 pages

Features

• Used Book in Good Condition

Amazon.com Review
From test tubes to the Wall Street IPO and beyond, this is the riveting true story of a start-up pharmaceutical company working to create an anti-AIDS drug. Scientifically accurate, yet written with an attention to plot, timing, dialogue, and development of character more characteristic of the best thrillers.

From Publishers Weekly
A startup pharmaceutical company is the focus of this intriguing look at the nexus of biotechnology and high finance; features a new epilogue by the author.
Copyright 1995 Reed Business Information, Inc.

From Library Journal
Werth, a freelance writer on science and business issues, chronicles Joshua Boger's start-up of Vertex, a biotechnology company dedicated to the discovery of new drugs. Boger, a successful organic chemist with Merck, left his position as a senior director to establish Vertex. He recruited an exceptional group of researchers with the aim of integrating the most advanced disciplines in molecular biology to develop an immune-suppressing drug used in organ transplants and a potent HIV protease inhibitor to help thwart AIDS. Werth also discusses Vertex's financing and initial public stock offering. Recommended for science and business collections in public libraries and for special libraries in the pharmaceutical industry.
- Bruce Slutsky, New Jersey Inst. of Tech. Lib., Newark
Copyright 1994 Reed Business Information, Inc.

Most helpful customer reviews

35 of 37 people found the following review helpful.
difficult, fascinating, and compelling birth of a company
By Robert J. Crawford
This is the story of the first few years of Vertex, a bioventure that sought to create drugs that were constructed molecule by molecule - it is supposed to be "rational drug design". In exchange for allowing the company to check his work for accuracy and proprietary disclosures, Werth was admitted into the inner circle of the company, with both executives and scientists, for four years.

Werth offers masterful descriptions of both the science and the intricacies of the busisess deals. The work is similar to that of Tracy Kidder in "The Soul of a New Machine" and, in my opinion, of the same quality.

At the center of the story is Vertex's founding visionary, Joshua Boger, formerly a researcher at Merck. He reasoned that instead of screening soil samples and insect secretions in a hot or miss approach in thousands of petri dishes, he could design drugs atom by atom to bind to - and thus inactivate - molecules instrumental to the disease process. In theory, these drugs would be without side effects: because of the precision of the design, they would adhere to their target alone, allowing beneficial enzymes of other chem reactions to go on unimpeded.

Boger's first target molecule was FKBP, which he believed was a crucial agent of the immune system. By blocking it, he hoped to prevent the host's body from rejecting transplanted organs. While Boger was out raising money (eventually reaching $60 million), Vertex's researchers hunkered down to isolate and analyze FKBP, whose molecular mechanic remained poorly understood.

Unfortunately, what happened is a great example of the difficulties in marrying business to cutting-edge science: after over two years of pushing themselves to the brink of nervous collapse, Vertex scientists found difficulties with FKBP. Even worse, Boger's arch rival, a prof at Harvard, discovered why. The prof beat VErtex, Werth argues, because he remained outside the venture capital game and could thus concentrate totally on the science and could openly collaborate with them rather than hide proprietary results.

Nonetheless, driven and confident as ever, Boger turned his scientific team onto the new problem. Thru all of this, Boger comes off as a fascinating character: the son of a suicide, he is unshakably convinced that he can bend nature as well as the business world to his will. The reader sees what lies behind the herculean efforts of him and his team.

Warmly recommended as a rivetting tale of human endeavor that embraces the true complexity.

14 of 15 people found the following review helpful.
Fast-paced and Insightful
By EarlRandy
I first read this book nearly two years ago as research for a novel I was writing. Recently, I turned to it once more to pick up a few terms and found myself reading chapter after chapter!
This non-fiction tale has enough twists and turns and drama to match any thriller on the market. An informative and engaging tale of a pharmaceutical start-up and the people involved. Joshua is interesting enough that the book could have been solely about him, but he isn't the only one. All of the players in this ego-driven mega-drama are interesting on many levels.
Who would I reccomend this book to? Anyone who likes a well-told story. A background in medicine is not needed, and neither is a knowledge of business practices. All you need to enjoy this book is a brain . . . and a night light because you'll be reading this book deep into the night.

5 of 5 people found the following review helpful.
The Billion Dollar Molecule - One Company's Quest...
By thesheerans
A thouroughly enjoyable read, Werth sheds light on the personaliteis and complexities of an amazing and multifaceted business. Throughout, the author uncovers the unseen deal-making, hand-wringing, and fist clenching that dominate the start of Vertex, a strucure-based paharmaceutical firm.
I particularly enjoyed the background on the Boger-Schreiber collaboration and rivalry, and the ensuing rivalry in Vertex's own labs. Further, following the last few years of Vertex's ups and downs via the Internet has been thoroughly enjoyable.
Werth's style is easliy read, and his obvious unhindered access to Vertex and its people make the story enjoyable, suspenseful, and dramatic.

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[S881.Ebook] Download Mastering Revit Structure 2010, by Thomas S. Weir, Jamie D. Richardson, David J. Harrington

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Mastering Revit Structure 2010 covers both the basics and the advanced features and functions. Written by a team of authors who are deeply involved with the Revit community, Mastering Revit Structure 2010 explains the tools and functionality in the context of professional, real-world tasks and workflows. With hands-on tutorials to demonstrate the concepts, Mastering Revit Structure 2010 is perfect for anyone who needs to learn Revit Structure 2010 quickly and thoroughly. Additionally, there is a companion Web site offers before-and-after tutorial files for downloading.

• Sales Rank: #1553630 in eBooks
• Published on: 2010-12-22
• Released on: 2010-12-22
• Format: Kindle eBook

From the Back Cover
These three authors are a virtual “dream team” of Revit Structure expertise and industry knowledge.
—From the Foreword by Nicolas Mangon, Building Industry Director, Autodesk, Inc.

Structure Your Designs the Revit Way

Whether you're a structural engineer, designer, or draftsperson, now you can become quickly productive in Revit Structure 2010 with this comprehensive guide. The expert author team combines years of engineering and Revit experience to give you detailed instruction in basic concepts and professional techniques, while also revealing Revit tricks, tips, and workarounds not well documented elsewhere.

Learn how to model structural elements, then delve into advanced family creation, standards development, modeling, visualizing, and analytics. Explore Revit Structure 2010's enhanced worksharing capabilities, the newly updated user interface, and improved interoperability with other programs. Packed with real-world solutions and striking examples in full color, this is your indispensable guide to Revit Structure.

Coverage includes:

• Understanding how parametric modeling frees you to focus on your designs
• Exploring the broad array of tools in Revit Structure's user interface
• Viewing and referencing plan, section, elevation, and model views—simultaneously—while you design
• Applying scheduling, annotation, and dimensioning info as you go, for speedier workflows
• Creating and presenting 3D visualizations that bring your designs to life
• Using analytical tools to test and simulate, then refine your designs
• Adding custom content and building your own component libraries

About the Author

About the Authors

Thomas S. Weir is Director of BIM and CAD operations at Brandow & Johnston in Los Angeles. He is co-chairman and founder of the L.A. Revit Users Group, moderates the Autodesk User Group International (AUGI) Revit Structural forum, teaches Revit Structure at Autodesk University, and wrote the first Autodesk Official Training Courseware for Revit Structure. Jamie D. Richardson is an associate and CAD/BIM Manager for Ericksen Roed & Associates in the Twin Cities area. He speaks at Autodesk University, is active in his local Revit User Group, and mentors students at local technical colleges. David J. Harrington, former president and former board member of AUGI, is currently a structural designer for Walter P. Moore. He writes for industry publications, is the technical editor for AUGIWorld magazine, teaches at Autodesk University, and maintains a popular blog (caddhelp.blogspot.com).

Most helpful customer reviews

7 of 7 people found the following review helpful.
Great Book
By Mark W. Kiker
When I first opened this book the information it leaped off the page. The presentation of the data was well laid out and I notice things like that. The font selection was great and the good use of white space was impressive. Illustrations and screen shots were on just about every page.

The wonderful thing was the joy did not stop there. This book does not disappoint. Scattered throughout the book are "Real World Scenarios". Little vignettes of information that came from the practical minds of the authors. Things that they wanted to share apart from the systematic presentation of the topic. Also mixed in are questions that you should ponder - like "how much should I model?" that encourage you to think beyond the basics.

The book is also filled with step by step exercises. Each starts from a data set that can be downloaded from a companion website listed on page 51 (may be hard to find).

Insider tips and tricks are placed in the book to assist with the problems that you may encounter or to give you options. One that I found refreshing was the trick of using a wall to represent a column. They caution you that this may give the proper appearance but lack the property data you might need.

Each chapter ends with "the Bottom Line". A collection of reminders and questions that recall the content of the chapter and press you on to find new ways to use these tools. Clever idea.

One of the best chapters or sections is on worksharing and worksets. This presentation of the work flow and concepts is one of the best I have seen.

Just when you thought that the book was jammed with just about everything you could think of, there is a multi-page full color section on real projects. If you thought that structural work was all about square boxes, you need to look again. Seeing the bones of a facility in color is fascinating. No longer can you say "Revit can't do that" (well almost). There are small projects and very large projects shown.

Now you know that I am big on standards, so Chapter 17 is of great interest to me. Imagine a whole chapter on standards - GREAT!! Anyway, you can tell it is written by industry experts with many years of background in the trenches of CAD and BIM. Included in this chapter are tips on what to do and not do, how to make small changes that impact the whole team for the good and how to tweak Revit Structure to perform better.

To top it all off the Appendix is an escorted tour of the color gallery I mentioned above. These authors give you a personal guided tour of the projects they have worked on. Zooming in on details and explaining the nuances of the design and how they modeled it. What a value.

All in all, this book is a very valuable addition to your library. I would recommend it to novice and expert alike. The reward of digging into the meat of this book is that your Revit knowledge will expand and your ability to muscle the software into submission will increase.

4 of 5 people found the following review helpful.
MAstering Revit Structure 2010
By M. J. Ballou
The book appears to be a very thorough introduction to the subject. I am glad I purchased the book, and have read about 110 pages or so. I would recommend this as a good introduction to the Revit program and its capabilities for production of structural engineering designs.

0 of 0 people found the following review helpful.
FAST DELIVERY
By FERNANDO HEREDIA
first of all thanks to amazon for send me this book in less time that I expected.
second, I start reading it quite slow because I have no time left, anyway I found it very friendly and with useful topics just as if you are in a classroom with this guys giving you all this advice.
I hope I still enjoy it till it's last page. thks again. FH

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[R156.Ebook] Download Indian Paratha Recipes (Volume 1), by Martin Pretty

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Indian Paratha Recipes (Volume 1), by Martin Pretty

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Paratha or Parantha is a category of unleavened Indian bread made with whole wheat flour, a dish wish of universal appeal. Paratha is a very special Indian Breakfast recipe. Parathas are made in each & every home & its own ways of making.

• Sales Rank: #2632502 in Books
• Published on: 2016-02-06
• Original language: English
• Dimensions: 9.00" h x .7" w x 6.00" l,
• Binding: Paperback
• 30 pages

Most helpful customer reviews

2 of 2 people found the following review helpful.
I love someone from India and getting to know a bit ...
By Anja Young
Paratha is a new term for me, so the concept is fresh too. I have a grand time reading this book because it made me understand a part of the Indian culture more. I love someone from India and getting to know a bit of his culture and life is very important for me. This book has some amazing recipes too. I hope to try them so that I will feel a little closer to India. It has been a very nice time reading this.

0 of 0 people found the following review helpful.
Soft, Tasty & flavored Paratha recipes. I liked these recipes.
By GREG RICHARDSON
This cookbook is amazing and helpful. By the help of this book I have learned about Indian Paratha recipes. I heard this kind recipe name before, but did not know the main recipe. Last week my friend suggested me about this book and I did not late to purchase this book.
I am a food lover and I always like to read a recipe book. It is true that Paratha is a very special and most popular Indian breakfast recipe. Inside of this book I have found some popular and delicious recipes. The author of this book has described every recipe very clearly and step by step. I already tried one of them last night and it was really soft & tasty. If you want to learn this kind of recipe, then grab this book immediately.

0 of 0 people found the following review helpful.
Great tasting recipes!
By Ian
If you are looking for some great tasting Indian Paratha recipes, look no further than this book. The author provides a lot of recipes that not only teach you how to cook and prepare the bread, but how to cook it with different ingredients and foods. I now have several different recipes in my repertoire that I can go to when cook paratha. I have even shared this with some of my friends and they are now using it to cook all the time. Again, download this book if you are interested in cooking up some great paratha recipes!

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JavaScript is the brains of your Web page—it enables you to modify a document’s structure, styling, and content in response to user actions without requesting new pages from the server. Scriptin' with JavaScript and Ajax teaches you how to master this powerful and elegant language so you can develop intuitive user interactions that take the user experience to new levels of sophistication and responsiveness.

Today’s application-like Web experiences (such as Salesforce.com and Google Maps) and Web 2.0 sites (such as Flickr.com and Twitter) are powered by JavaScript and Ajax. Using the techniques shown in this book, you will be able to start creating similar experiences in the sites you design.

Scriptin' with JavaScript and Ajax will teach you how to:

• Start developing with JavaScript fast!

• Write lightweight but powerful object-oriented code

• Modify the Document Object Model

• “Progressively enhance” your pages with JavaScript to provide the highest levels of accessibility to all users

• Learn sophisticated techniques for making your pages respond to user actions

• Use the downloadable Scriptin’ library of helper functions to speed development and ensure cross-browser compatibility

• Use Ajax scripting techniques to update specific areas of the page with data from the server

• Create powerful interface interactions, such as sliding panels and tree menus

• Evaluate frameworks such as jQuery and Prototype to find the best one for your needs

• Build an online application that looks and responds like a regular desktop application

• Easily adapt the Scriptin’ code examples for use in your own projects—download them at www.scriptinwithajax.com

• Sales Rank: #1959441 in Books
• Published on: 2009-08-27
• Original language: English
• Number of items: 1
• Dimensions: 9.12" h x .56" w x 7.48" l, 1.36 pounds
• Binding: Paperback
• 312 pages

From the Back Cover
JavaScript is the brains of your Web page-it enables you to modify a document's structure, styling, and content in response to user actions without requesting new pages from the server. Scriptin' with JavaScript and Ajax teaches you how to master this powerful and elegant language so you can develop intuitive user interactions that take the user experience to new levels of sophistication and responsiveness.
Today's application-like Web experiences (such as Salesforce.com and Google Maps) and Web 2.0 sites (such as Flickr.com and Twitter) are powered by JavaScript and Ajax. Using the techniques shown in this book, you will be able to start creating similar experiences in the sites you design.
Scriptin' with JavaScript and Ajax will teach you how to:
Start developing with JavaScript fast!Write lightweight but powerful object-oriented code Modify the Document Object Model "Progressively enhance" your pages with JavaScript to provide the highest levels of accessibility to all usersLearn sophisticated techniques for making your pages respond to user actionsUse the downloadable Scriptin' library of helper functions to speed development and ensure cross-browser compatibilityUse Ajax scripting techniques to update specific areas of the page with data from the serverCreate powerful interface interactions, such as sliding panels and tree menusEvaluate frameworks such as jQuery and Prototype to find the best one for your needsBuild an online application that looks and responds like a regular desktop applicationEasily adapt the Scriptin' code examples for use in your own projects-download them at www.scriptinwithajax.com

About the Author
Charles Wyke-Smith (Charleston, SC) has been creating web sites since 1994 and currently User Experience Architect for Benefitfocus. Charles was VP of Web Development for eStar.com, a celebrity information site, and has provided web design and consulting services to companies including Wells Fargo, ESPN Videogames, and The University of California, San Francisco. His work today focuses on site development, with an emphasis on user experience, information architecture, and interface design. Charles has taught classes in multimedia and interface design and speaks at many industry conferences.

Most helpful customer reviews

1 of 1 people found the following review helpful.
Could have been brilliant!
By Schliemannski
I have to agree with JonG's review, though I give it an additional star, this book is full of text and code errors. In the first few pages of Chapter 1 alone I found plenty of errors. The code examples for simple_form_stem1.php, simple_form_step2.php, and form_functions.php require numerous fixes before they ran successfully on my local server.

On the plus side, I'm learning good testing and debugging techniques as I correct the code along the way.

I still recommend it (as well as his other equally flawed books.) You'll get something positive out of them, but you'll have to work a bit harder than intended.

And where are the errata sheets? I couldn't find them anywhere on his site.

31 of 32 people found the following review helpful.
Some good content, brought down by loads of errors.
By JonG
I'm an experienced programmer, but fairly new to JavaScript.

I liked how the book didn't get stuck on the basics and jumped quickly into real examples of applying JavaScript to enhance a website.

However, as more code appeared on the pages, so did a lot more mistakes. A number of these seemed to be the result of going through several revisions and not updating all references to the code being discussed, but many were pretty inexcusable such as:

- Glaring syntax errors
- Inconsistent names / referencing functions or objects that don't exist
- Incomplete / non-functional code in places

I was able to get something out of this book and didn't get stumped by many of these mistakes (although there were certainly some WTF moments), but I kept imagining a poor novice programmer getting totally confused by parts of the text. There were also some bad practices demonstrated in places. The number of errors is severe enough that I wouldn't recommend this book to friends or colleagues.

1 of 1 people found the following review helpful.
Very clear and concise.
By mattrweaver
I have used a previous book by Charles Wyke-Smith, Codin' for the Web, and was excited to see that he was coming out with one on Javascript/Ajax. You'll notice that his books are a lot thinner than other books aimed at beginners. He distills lessons down to essentials and manages to present concepts in ways that are more accessible to noobs.

I've done some javascript, but haven't learned it in a systematic way, and his books simplify syntax so that those of us who haven't programmed since basic or pascal back in the 80s, or perhaps those who have never programmed at all, can get our heads around these concepts.

The prose is easy to read and the examples -- unlike so many other books of this sort -- are clearly explained.
Often I've had trouble relating the examples used in programming books to projects that I am working on. Somehow Wyke-Smith explains things well enough so you can understand how to break your own projects down into the requisite parts.

This book includes discussion of jquery, and the relationships between server-side languages, web interfaces, etc.

All in all, very useful and helpful.

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• Published on: 1600
• Binding: Hardcover

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[H175.Ebook] PDF Ebook Freedom Formula For Physicians: A Prescription for First-Class Financial Health for Doctors, by Dave Denniston CFA

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When doctors saved his daughter’s life when she was born nearly four months
premature, Dave Denniston, CFA, instantly knew what his mission in life would be—
fatherhood and helping doctors. He has spent every day since using his financial
expertise to help physicians to realize their financial dreams.
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• Sales Rank: #933122 in Books
• Published on: 2015-02-16
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x .47" w x 5.98" l, .66 pounds
• Binding: Paperback
• 218 pages

Most helpful customer reviews

1 of 1 people found the following review helpful.
I would highly recommend this book to any physician who wants to get ...
By Kyle N. Klingler
As a physician just starting out in practice after residency, I received a copy of Dave's book and found it extremely helpful. He talks about the importance of having a plan mapped out and getting the right people in your corner. He explained things in an easy-to-understand manner. We felt it helped get us on the right track as we were learning how to navigate our income and the different expenses that come with a practice buy-in and insurance. I would highly recommend this book to any physician who wants to get a handle on their finances.

0 of 0 people found the following review helpful.
Freedom Formula for Physicians is a great financial resource for physicians young and old
By Sarah
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0 of 0 people found the following review helpful.
It's never too late!
By keith a cox
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[Y868.Ebook] Download PDF The High-Speed Internal Combustion Engine, by H R Hempson, J G Ricardo

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• Sales Rank: #2591616 in Books
• Published on: 1968
• Binding: Hardcover

Most helpful customer reviews

1 of 1 people found the following review helpful.
Basic text
By Ken
This is the basic text on internal combustion engines. No other can replace it.

2 of 2 people found the following review helpful.
The classic study on the infernal combustion engine
By J. Bankston
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1 of 1 people found the following review helpful.
Classic.
By lorin budzinski
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